If prolonged opioid use is required inside of a pregnant female, suggest the individual of the chance of neonatal opioid withdrawal syndrome and make certain that suitable treatment will likely be out there. (five.3)
Geriatric Population Inside the geriatric inhabitants, age has no effect on the pharmacokinetics of hydromorphone.
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The pharmacokinetics of hydromorphone in individuals with extreme hepatic impairment hasn't been examined. An additional increase in Cmax and AUC of hydromorphone Within this group is expected and will be taken into account when picking a beginning dose [see Medical Pharmacology (twelve.three].
Misuse and abuse of DILAUDID INJECTION raises chance of overdose, which can bring on central nervous system and respiratory depression, hypotension, seizures, and Loss of life. The danger is increased with concurrent abuse of DILAUDID INJECTION with Liquor and/or other CNS depressants.
Pregnant or planning to grow to be pregnant. Extended usage of DILAUDID Tablets and DILAUDID Oral Solution throughout pregnancy might cause withdrawal indications in your new child baby that can be lifetime-threatening if not recognized and treated.
Inform your Health care company if you take any of the next for the reason that these medicines connect with Viagra® and generic Viagra®:
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Inspect parenteral drug goods visually for particulate matter and discoloration just before administration, whenever solution and container allow. A slight yellowish discoloration may well create in DILAUDID INJECTION.
Viagra® and generic Viagra® may possibly have an affect on just how other medicines do the job, together with other medicines may perhaps impact just how Viagra® and generic Viagra® will work, leading to Uncomfortable side effects.
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To cut back the potential risk of respiratory depression, correct dosing and titration here of DILAUDID INJECTION is critical [see DOSAGE AND ADMINISTRATION]. Overestimating the DILAUDID INJECTION dosage when changing patients from Yet another opioid product may end up in a fatal overdose with the very first dose.
The pharmacokinetics of hydromorphone are impacted by hepatic impairment. Due to greater exposure of hydromorphone, individuals with reasonable hepatic impairment ought to be started off at 1-fourth to 1-fifty percent the proposed commencing dose based on the degree of hepatic dysfunction and carefully monitored through dose titration.